Publications

Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLCβ). 

National Center for Biotechnology Information. PubChem BioAssay Database; AID=720700, https://pubchem.ncbi.nlm.nih.gov/bioassay/720704.

Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLCγ1).

National Center for Biotechnology Information. PubChem BioAssay Database; AID=720700, https://pubchem.ncbi.nlm.nih.gov/bioassay/720700.

A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes

Huang, W., Hicks, S. N., Sondek, J., & Zhang, Q. (2011). A fluorogenic, small molecule reporter for mammalian phospholipase C isozymes. ACS Chemical Biology, 6(3), 223–228. http://doi.org/10.1021/cb100308n

Small molecule inhibitors of phospholipase C from a novel high-throughput screen

Huang, W., Barrett, M., Hajicek, N., Hicks, S., Harden, T. K., Sondek, J., & Zhang, Q. (2013). Small molecule inhibitors of phospholipase C from a novel high-throughput screen. The Journal of Biological Chemistry, 288(8), 5840–5848.  http://doi.org/10.1074/jbc.M112.422501

Charge Shielding of PIP₂ by Cations Regulates Enzyme Activity of Phospholipase C

Jong Bae Seo, Seung-Ryoung Jung, Weigang Huang, Qisheng Zhang, Duk-Su Koh, PLoS One,11;10(12):e0144432 (2015), doi.org/10.1371/journal.pone.0144432

Interactions Between Autotrophic and Heterotrophic Strains Improve CO₂ Fixing Efficiency of Non-photosynthetic Microbial Communities

Hu J, Wang L, Zhang S, Xi X, Le Y, Fu X, Tsang Y, Gao M., Appl Biochem Biotechnol 176(5):1459-71 (2015), doi: 10.1007/s12010-015-1657-4.

A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes

Weigang Huang, Xiaoyang Wang, Stuart Endo-Streeter, Matthew Barrett§, Jarod Waybright, Christian Wohlfeld, Nicole Hajicek, T. Kendall Harden, John Sondek and Qisheng Zhang, JBC Papers in Press (2017) Latest version at http://www.jbc.org/cgi/doi/10.1074/jbc.RA117.000926, doi: 10.1074/jbc.RA117.000926

Membrane-induced Allosteric Control of Phospholipase C- Isozymes

Thomas H. Charpentier, Gary L. Waldo, Matthew O. Barrett, Weigang Huang, Qisheng Zhang, T. Kendall Harden and John Sondek, J Biol Chem 289(43):29545–29557 (2014), doi: 10.1074/jbc.M114.586784.

LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis

Janjanam J, Zhang B, Mani AM, Singh NK, Traylor JG Jr., Orr AW, Rao GN, J. Biol. Chem293(9): 3088–3103 (2018), doi: 10.1074/jbc.RA117.000866.

PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration

Jagadeesh Janjanam, Giri Kumar Chandaka, Sivareddy Kotla, and Gadiparthi N. Rao, Mol Biol Cell, 26 (2015), doi: 10.1091/mbc.E15-08-0570

Pharmacologic inhibition of phospholipase C in the brain attenuates early memory formation in the honeybee (Apis mellifera L.)

Suenami S, Iino S, Kubo T, Bio Open 7(1), bio028191. doi:10.1242/bio.028191 (2018), doi: 10.1242/bio.028191.