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Products > Proteins > PLCs

PLCs

KXTbio provides high quality PLCs that help researchers understand the diverse cell functions that are mediated by this group of proteins, as well as, the development of related diseases and the maintenance of homeostasis within the cells.

ProteinWeightSKUAdditional Information
PLCβ120 µgP0109SClick here for more details
PLCβ220 µgP0110SClick here for more details
PLCβ320 µgP0108SClick here for more details
PLCγ120 µgP0103S
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PLCγ220 µgP0104S
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PLCδ1100 µgP0107SClick here for more details

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Related publications

Zhang Q et al.; Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLCβ). National Center for Biotechnology Information. PubChem BioAssay Database; AID=720700,
+ Read abstract
Extracellular stimuli including hormones, growth factors, and neurotransmitters promote activation of phospholipase C (PLC) isozymes and cleavage of the membrane lipid phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) into the classical second messengers, diacylglycerol and inositol 1,4,5- trisphosphate (IP3) [1]. These second messengers coordinately control numerous signaling cascades through the mobilization of intracellular Ca2+ stores and the activation of protein kinase C. Aberrant regulation of PLCs contribute to diverse human diseases including cancer [2-4], cardiovascular diseases [5-6], and neuropathic pain [7], as well as schizophrenia and epilepsy [5, 8-9]. Consequently, small molecule PLC inhibitors will be valuable pharmacological tools to dissect the roles of PLCs in development and disease, and could potentially serve as candidates for drug development. Read the full article here

Zhang Q et al., Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-γ1). National Center for Biotechnology Information. PubChem BioAssay Database; AID=720700,
+ Read abstract
Extracellular stimuli including hormones, growth factors, and neurotransmitters promote activation of phospholipase C (PLC) isozymes and cleavage of the membrane lipid phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2) into the classical second messengers, diacylglycerol and inositol 1,4,5- trisphosphate (IP3) [1]. These second messengers coordinately control numerous signaling cascades through the mobilization of intracellular Ca2+ stores and the activation of protein kinase C. Aberrant regulation of PLCs contribute to diverse human diseases including cancer [2-4], cardiovascular diseases [5-6], and neuropathic pain [7], as well as schizophrenia and epilepsy [5, 8-9]. Consequently, small molecule PLC inhibitors will be valuable pharmacological tools to dissect the roles of PLCs in development and disease, and could potentially serve as candidates for drug development. Read the full article here

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