PLCglow is the only soluble, fluorescent reporter of phospholipase C (PLC) isozymes will lead the pathway to smarter, safer and more effecive drug screening and biochemical research of this target. Unique properties include:

  • Soluble, fluorescent reporter of phospholipase C (PLC) isozymes.
  • Specifically designed for mammalian PLCs
    • WH-15 was specifically designed to reflect the endogenous substrate, phosphatidylinositol 4,5-bisphosphate( PIP2).  The two substrates produce similar values of Km and Vmax with various mammalian PLCs.
    • Will also work with the more promiscuous bacterial PLCs.
  • Robust output
    • Great than six-fold change in fluorescent when hydrolyzed by PLCs.
  • Works with all enzymatically active PLC isozymes.
    • Will not report activities of other phospholipases (PLD, PLA2).
    • Works with purified PLCs and cellular lysates.
  • No comparable reagent on the market.
    • Replaces tedious metabolic labeling with radioactive inositol to measure PLCs.
  • Stable up to a year at -80oC or 3 weeks upon resuspensions in water.

 

 

For larger quantities of PLCglow, please send us an email for pricing. 

Available products

PLCglow®, 50μg

KCH-0001
USD 350.00

PLCglow®, 1 mg

KCH-0002
USD 6,650.00